Helicase

The enzyme responsible forming the replication fork* during DNA* replication. It works by unwinding and separating the two strands of DNA that make up the double helix. The separation of the two strands is needed to allow DNA polymerase* access to the nucleotides* that make up each strand.

Helicase is only responsible for the initial separation. Additional proteins, called helper proteins, are required to keep the replication fork open.

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